Small molecules are frequently used as dyes, labels and markers to visualize and probe biophysical processes withing cells. Though the optical properties and excited-state relaxation pathways of these molecules have been studied intensively, [1, 2] very little is generally known about the light-driven excited-state reactivity of such systems when placed in live cells. In this work, we...
Nitric oxide (NO) plays an important role in many biological signalling processes including blood pressure regulation, neurotransmission, inflammatory response, and programmed cell death (apoptosis).[1,2] Although the NO donors have been useful research tools, many of them release NO via spontaneous decomposition, so that it is difficult to control NO release.[3] To overcome this problem, NO...
Early detection of bacteria forming biofilms can have a significant impact in a variety of fields such as healthcare, food industry and environment protection. Development of highly sensitive, specific, and cost-effective biosensors for bacteria detection is necessary for the prevention of infections, especially due to increase in the number of new multi-drug resistant bacteria....
Endothelial dysfunction (ED) is a strong predictor of atherosclerosis. To prevent disease development new method of ED detection should be created. Diagnostics of the dysfunction in one sample requires two parameters sensitive system (Logic Gate). For ED nitric oxide (NO) and calcium cations were chosen as interdependent parameters for ED detection. In this study, we are focusing on $Ca^{2+}$...
Endothelial dysfunction (ED) has been linked to the development of many lifestyle diseases such as atherosclerosis, diabetes or hypertension 1 and the phenotype of endothelial dysfunction is often linked to altered capacity of endothelial regeneration unable to repair vascular dysfunction. Therefore, new methods to study endothelial cell proliferation are desirable.
Raman imaging of...
Bodipy Derivatives Sensitized Triplet Triplet Annihilation Upconversion in Solution and Liposomes
Amrutha Prabhakaran, Ruben Arturo Arellano Reyes, and Tia E Keyes*
aSchool of Chemical Sciences and National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland
Abstract
Triplet-triplet annihilation upconversion (TTA-UC) is a photophysical phenomenon in which two low energy...
The biosensing platforms have potential applications in the diagnosis of disease as sensitive, durable, portable and inexpensive systems. The use of Ferrite Magnetic Beads (FMBs) in biosensors for high-performance clinical diagnosis is gaining popularity due to their low toxicity and ability to be manipulated by an external magnetic field. FMB-based biosensors necessarily involve well-tuned...
