Ion-beam cancer therapy is used for the treatment of cancer. The initial ions in the beam are entering the biological material with energies of a few million eV and are generating secondary electrons by ionization processes. The secondary electrons can cause more ionization or initiate excitation processes, which can cause break some chemical bonds and cause the death of the affected cells....
The study and synthesis of BODIPY dyes have become widespread owing to their favorable properties such as large molar absorption coefficients, high fluorescence quantum yields, excellent thermal and photochemical stability, good solubility as well as versatile functionalization1. A growing number of theoretical studies (see e.g.2,3,4) has also been performed. In this study (R.C. Sia, R.A....
Over the past decades, endothelial dysfunction and atherosclerosis have become a significant issue across the world. Nitric oxide (NO), along with calcium, is a primary physiological mediator for detecting endothelial dysfunction as NO plays a crucial role in the proper functioning of endothelial cells. On the other hand, triplet-triplet annihilation upconversion (TTA-UC) has become a powerful...
Nitric oxide (NO) is a crucial molecule for the function of the vascular system. NO releasing compounds are widely used for researching the effects of NO as well as therapies of cardiovascular and skin disorders. The amount of NO released is the conclusive element for wanted effects and because of this, Ruthenium-terpyridine is a very important compound as it is possible to change...
Histone deacetylases (HDACs) constitute an epigenetic enzyme family that is implicated in cancer and a variety of other immunological, neurological, cardiac, and endocrine diseases. Development of novel HDAC isoform-selective inhibitors is necessary to improve their in vivo potency while reducing toxicity. The isoform selectivity of HDAC inhibitors is routinely measured in biochemical...
Endothelial dysfunction is the prime cause of many pathological conditions such as atherosclerosis, thrombosis, platelet aggregation, inflammation, and defective oxygen mechanism due to hypoxic conditions. The natural mechanism in maintaining vascular endothelium involves various signaling compounds and mechanistic factors such as fluid flow and shear stress. Among all signaling compounds,...
miRNAs are small, 22 nucleotide long RNA sequences. They are found in every cell type and perform the role of regulating gene expression. Research in the field has also identified free miRNA in a variety of bodily fluid. Their availability and their role in gene regulation make them attractive targets as biomarkers for the advanced detection of many diseases such as CVD, one of the leading...
