Understanding intracellular dynamics and concentrations of diverse intracellular analytes is key to develope novel diagnostic tools. Fluorescence-based molecular probes have proben to be key for intracellular imaging and sensing analytes of biological interest. Most of the currently available fluorescent probes are excited using ultraviolet or visible light, which results in high...
The design, synthesis and application of luminescent metal complexes as efficient theragnostic
agents have great significance in the field of medicinal chemistry [1]. Luminescent d‐metal ion
complexes are well-known for their therapeutic activities because of their unique
photochemical and photophysical characteristics [2]. 4-amino‐1,8‐naphthalimide derived
Tröger’s base (TBNap)...
Many studies have been devoted to investigation of phase separation and formation of lipid domains, which play crucial role in many biological processes. In the following study we measured the size and distribution of liquid-ordered (Lo)¬ phase domains in the wide range of buffer pH 1.7-9.0 and showed that there is a strong correlation between the size of the formed Lo phase domains and pH of...
From various electrical and mechanical studies, supported lipid bilayers (SLBs) have been realized to possess brilliant implementation potential in terms of technological application as biosensors and biocoatings1. Structure and dynamics of SLBs are modulated not only by lipid-lipid, lipid-protein interactions, but the interplay between lipids and the water hydrating the membrane plays a...
Polarity-sensitive fluorescent sensors constitute useful tools to quantify key biophysical properties of biomembranes, such as lipid order. However, prolonged acquisitions using these dyes are universally limited by dye photobleaching, i.e. the irreversible destruction of the sensor by the excitation light. This problem is aggravated in the case of super-resolution microscopy, due to the high...
